https://www.nature.com/articles/s41563-026-02625-3
[!abstract]+
由于神经元自身再生能力有限，脊髓损伤的治疗仍然十分困难。尽管神经祖细胞（NPC）疗法前景广阔，但移植细胞存活率不足、分化不受控制以及功能整合较弱等问题仍然限制着治疗效果。本文报道了一种名为NPCbots的生物混合微型机器人，该机器人通过将人诱导多能干细胞来源的NPC与磁电纳米颗粒整合而成，实现了无线磁导航和非侵入性神经元刺激。基于芯片实验室平台的NPCbots可实现规模化生产，并维持细胞的活性和分化能力。在斑马鱼脊髓损伤模型中，NPCbots经交变磁场刺激后，可诱导体内神经元和星形胶质细胞的快速分化，增强移植细胞在损伤部位的整合，并在3天内使斑马鱼的游泳和探索行为几乎完全恢复。在完全脊髓横断的非再生小鼠模型中，NPCbots至少在28天内耐受性良好，能有效定位到损伤部位，促进神经分化，并在4周内显著改善运动功能。这些结果表明，磁引导NPCbots联合非侵入性磁电刺激可促进临床前脊髓损伤模型中的神经修复和功能恢复。
Phys.org – 2 Jun 26
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Est. reading time: 2 minutes
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